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Case Reports
. 1982 Nov;7(5):663-6.
doi: 10.1016/s0190-9622(82)70148-3.

Premature epiphyseal closure in a child receiving oral 13-cis-retinoic acid

L M Milstone, J McGuire, R C Ablow
Case Reports

Premature epiphyseal closure in a child receiving oral 13-cis-retinoic acid

L M Milstone et al. J Am Acad Dermatol. 1982 Nov.

Abstract

A boy with epidermolytic hyperkeratosis was treated systemically for 4 1/2 years with 13-cis-retinoic acid. At the age of 10 1/2 years, he developed pain in his right knee and radiographic evidence of partial closure of the proximal epiphysis of the right tibia. Similar radiographic changes have been described in individuals ingesting excessive amounts of vitamin A.

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