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. 1982 Oct;79(20):6380-4.
doi: 10.1073/pnas.79.20.6380.

A neural cell adhesion molecule from human brain

D A McClain, G M Edelman

A neural cell adhesion molecule from human brain

D A McClain et al. Proc Natl Acad Sci U S A. 1982 Oct.

Abstract

We have used a crossreactive monoclonal antibody against a mouse neural cell adhesion molecule (N-CAM) to characterize and purify an antigen from embryonic and neonatal human brain. This antigen was identified as human N-CAM according to several criteria, including molecular weight, sialic acid content, amino acid composition, analysis of peptide fragments, reactivity with a variety of anti-CAM antibodies, and activity of the antigen in assays of cell and membrane vesicle aggregation. The findings make feasible an exploration of the possible role of N-CAM in various neurological disorders.

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