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. 1982 Dec;79(24):7842-6.
doi: 10.1073/pnas.79.24.7842.

Two human c-onc genes are located on the long arm of chromosome 8

B G Neel, S C Jhanwar, R S Chaganti, W S Hayward

Two human c-onc genes are located on the long arm of chromosome 8

B G Neel et al. Proc Natl Acad Sci U S A. 1982 Dec.

Abstract

We have used in situ chromosome hybridization techniques to map the human cellular counterparts (c-onc genes) of the transforming genes of two RNA tumor viruses on human meiotic pachytene and somatic metaphase chromosomes. We find that the human c-mos gene is located on chromosome 8 at a position corresponding to band 8q22 on the somatic map. The human c-myc gene is found on chromosome 8 at position 8q24. These regions on the long arm of chromosome 8 have been previously reported to be involved in specific translocations found in the M-2 subset of acute nonlymphoblastic leukemias. Burkitt lymphoma, and other forms of non-Hodgkin lymphoma, and a familial abnormality that predisposes to renal cell carcinoma. These results suggest that translocations of the human c-mos or c-myc genes may be causally related to neoplastic transformation.

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