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Case Reports
. 1978 Sep;67(5):667-70.
doi: 10.1111/j.1651-2227.1978.tb17821.x.

Disseminated Herpes simplex virus infection in ataxia-telangiectasia

A Ben-Zvi, D Soffer, S Yatziv
Case Reports

Disseminated Herpes simplex virus infection in ataxia-telangiectasia

A Ben-Zvi et al. Acta Paediatr Scand. 1978 Sep.

Abstract

The clinical and pathological features are described in a child with ataxia-telangiectasia, complicated by fatal disseminated herpes simplex virus infection. Herpes simplex virus was isolated from the patient's blood, and the histopathological findings in the skin, liver and adrenals were consistent with herpes simplex virus infection. The patient had a combined immune deficiency state, as a part of the ataxia-telangiectasia syndrome. She had imparied cellular immune response to herpes simplex virus and developed no antibodies against the virus. To our knowledge, this is the first fatal case of disseminated herpes simplex virus infection in ataxiatelangiectasia.

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