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Comparative Study
. 1982 Oct;79(19):6102-6.
doi: 10.1073/pnas.79.19.6102.

Sleep-promoting effects of muramyl peptides

J M Krueger, J R Pappenheimer, M L Karnovsky
Comparative Study

Sleep-promoting effects of muramyl peptides

J M Krueger et al. Proc Natl Acad Sci U S A. 1982 Oct.

Abstract

A muramyl peptide that induces excess slow-wave sleep in rats, rabbits, and cats has recently been isolated from human urine. We now report that synthetic acetylmuramyl-L-alanyl-D-isoglutamine ("muramyl dipeptide") and its lysyl derivative (acetylmuramyl-L-alanyl-D-isoglutaminyllysine) can mimic the somnogenic effects of the natural peptide. Both compounds are also pyrogenic and may cause other disturbances of autonomic function. The pyrogenic effects of intravenously administered muramyl dipeptide can be suppressed by previous treatment with acetaminophen without blocking the sleep-promoting effects.

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