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. 1978;19(2):285-97.
doi: 10.1186/BF03547633.

Combined therapeutic effect of dietary selenium and vitamin E on manifested VESD syndrome in weaned pigs

J Hakkarainen, P Lindberg, G Bengtsson, L Jönsson

Combined therapeutic effect of dietary selenium and vitamin E on manifested VESD syndrome in weaned pigs

J Hakkarainen et al. Acta Vet Scand. 1978.

Abstract
in English, German

By using a therapeutic dietary supplementation in pigs, which had developed the vitamin Ε and selenium deficiency (VESD) syndrome, the same amounts of α-tocopheryl acetate and selenium were found to be effective as under prophylactic conditions. The experiment thus supported the conclusions that the addition of 5 mg DL-α-tocopheryl acetate/kg and 135 μg selenium/kg to a diet, which contained only traces of vitamin Ε and selenium, represents a level of minimal requirement. Glutathione peroxidase activity in blood serum was used to evaluate the selenium status in pigs. A modified method for determination of tocopherol in fat tissue was described. The addition of 15 mg α-tocopheryl acetate/kg diet was demonstrated to be sufficient to maintain the tocopherol stores in body fat at an unchanged level.

Fodret åt avvanda grisar, vilka hade insjuknat i experimentellt framkallat vitamin E- och selenbrist (VESD)-syndrom, supplemen- terades i terapeutiskt syfte med α-tokoferylacetat och selen. Samma mängder av vitamin E och selen visade sig vara verksamma vid an- vändning i terapi som i profylax. Resultaten gav således stöd åt slut- satsen att 5 mg DL-α-tokoferylacetat och 135 μg selen/kg foder, vilket ursprungligen innehåller endast spår av vitamin E och selen repre- senterar ett minimibehov av dessa ämnen för avvanda grisar. Gluta- tionperoxidas-aktiviteten i blodserum användes som ett mått på gri- sarnas selenstatus. En modifierad metod för bestämning av tokoferol i fettvävnaden beskrevs. Tillsättning av 15 mg α-tokoferylacetat/kg foder visades vara tillräckligt för att behålla kroppsfettets tokoferol- förråd på oföråndrad nivå.

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