Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1980 Jan;17(1):13-5.
doi: 10.1128/AAC.17.1.13.

Effects of subminimal inhibitory concentrations of Erythromycin, Clindamycin, and Pristinamycin on the penicillinase production of Staphlyococcus aureus

J Michel, P Stessman, J Stessman
Comparative Study

Effects of subminimal inhibitory concentrations of Erythromycin, Clindamycin, and Pristinamycin on the penicillinase production of Staphlyococcus aureus

J Michel et al. Antimicrob Agents Chemother. 1980 Jan.

Abstract

The influence of subminimal inhibitory concentrations of erythromycin, clindamycin, and pristinamycin on the penicillinase production of Staphylococcus aureus was tested in 12 strains. Of the 36 experiments performed, 16 (44%) showed a lack of influence, 10 (28%) displayed an increase, and 10 revealed a decrease in penicillinase activity. The maximal effect produced was generally induced by concentrations ranging from 1/4 to 1/32 the minimal inhibitory concentration, irrespective of the susceptibility of the strain to the drug. In spite of the fact that the drugs are closely related, they sometimes produced opposite effects on the same strain.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. J Bacteriol. 1958 Feb;75(2):125-9 - PubMed
    1. Bacteriol Rev. 1968 Dec;32(4 Pt 2):493-528 - PubMed
    1. J Antimicrob Chemother. 1977 Sep;3(5):525-7 - PubMed
    1. Proc Natl Acad Sci U S A. 1976 Oct;73(10):3386-90 - PubMed
    1. Chemotherapy. 1977;23(1):32-6 - PubMed

Publication types

MeSH terms