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. 1980 Jan;23(1):24-9.
doi: 10.1002/art.1780230105.

Deficiency of T cell mediated regulation of anti-DNA production in systemic lupus erythematosus

J D Clough, S A Frank, L H Calabrese

Deficiency of T cell mediated regulation of anti-DNA production in systemic lupus erythematosus

J D Clough et al. Arthritis Rheum. 1980 Jan.

Abstract

Isolated B cells from normal subjects and patients with systemic lupus erythematosus (SLE) could be stimulated to produce IgM anti-DNA with pokeweed mitogen. Normal but not SLE allogeneic T cells abrogated this response. Normal but not SLE autologous T cells promoted a switch from IgM to IgG anti-DNA production. SLE is characterized by at least two types of immunoregulatory abnormalities: a defect in T suppressor function and a defect in the IgM to IgG switchover.

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