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Case Reports
. 1980;133(1):51-6.
doi: 10.1007/BF00444755.

Immunocytological studies in a case of Bruton's disease

A Statz, G R Krueger, B Roth, E Gladtke
Case Reports

Immunocytological studies in a case of Bruton's disease

A Statz et al. Eur J Pediatr. 1980.

Abstract

Immunopathological findings in a case with infantile X-linked agamma globulinemia (Bruton's disease) are reported and compared to similar data from two cousins of the patient. Besides a severe decrease in B-lymphocytes in blood and lymph node, residual B-cells showed an almost total defect in Ig surface receptor expression. In addition, there was an unusual lymphocyte population which apparently exhibited E-rosette formation (i.e. T-cell characteristics) and phagocytosis. The data suggest that in Bruton's disease there may be a disturbance of the T-cell system besides the well known B-cell deficiency.

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