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. 1980 Mar;12(1):172-4.

Virus-immune cytotoxic T-cell activity following negative selection of alloreactive precursor lymphocytes

J R Bennink, P C Doherty
  • PMID: 6966098

Virus-immune cytotoxic T-cell activity following negative selection of alloreactive precursor lymphocytes

J R Bennink et al. Transplant Proc. 1980 Mar.

Abstract

Results obtained using negative selection protocols indicate that it is possible to obtain vaccinia-virus-specific killing of cells expressing H-2 types other than those encountered during physiologic development in thymus. This response has been found to be neither reciprocal for different H-2 types, nor identical for influenza and vaccinia viruses. Prior priming with virus apparently suppresses the capacity of T cells to be sensitized to H-2-different virus-infected cells.

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