Detection of critical coronary lesions with treadmill exercise testing: fact or fiction?

Abstract

This study was designed to determine whether treadmill exercise testing could identify patients with critical coronary lesions. Critical lesions were defined as obstruction of the left main coronary artery or concomitant narrowing of the left anterior descending and circumflex coronary arteries proximal to any major branches. The time of onset and degree of S-T segment depression were evaluated in 25 patients with critical lesions and in 50 patients with other types of lesions. S-T segment depression of 2 mm or more was present in 82 percent of patients with left main coronary disease and in 71 percent of patients with left main coronary equivalent lesions (both P less than 0.02 when compared with 36 percent of patients with other lesions). However, half of the 37 patients with this degree of S-T segment depression had noncritical lesions. Ischemic changes appearing in the first 3 minutes of exercise were seen in 63 percent of patients with left coronary disease and 35 percent of the patients with left main coronary disease equivalent lesions (P less than 0.001 and P less than 0.002, respectively, when compared with only 6 percent of patients with other lesions). The incidence of triple vessel disease was significantly greater in patients with critical lesions (55 percent in patients with left main coronary disease and 71 percent in those with the left main coronary equivalent lesions versus 10 percent in those with other lesions) (P less than 0.01). S-T segment depression of 2 mm or more is not a good indicator of critical coronary lesions because it has a low level of specificity. Consideration of the time of onset of ischemic changes adds to its usefulness, but it does not permit a definitive diagnosis in individual patients.