Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1980 Mar;77(3):1627-31.
doi: 10.1073/pnas.77.3.1627.

Autoantibody to centromere (kinetochore) in scleroderma sera

Y Moroi, C Peebles, M J Fritzler, J Steigerwald, E M Tan

Autoantibody to centromere (kinetochore) in scleroderma sera

Y Moroi et al. Proc Natl Acad Sci U S A. 1980 Mar.

Abstract

Sera from patients with scleroderma contained several autoantibodies to nuclear antigens which were distinguished by different patterns of nuclear immunofluorescence staining. One of these autoantibodies reacted with centromeric regions of chromosomes. In chromosome spreads, the staining appeared as two small spheres at the centromere, resembling kinetochores. The antigenic determinant appeared to be a protein or polypeptide tightly bound to DNA. The autoantibody was reactive with centromeres of cells derived from humans, mice, and Chinese hamsters. The autoantibody was present in high frequency in the calcinosis/Raynaud's phenomenon/esophageal dysmotility/sclerodactyly/telangiectasia variant (CREST) of scleroderma.

PubMed Disclaimer

References

    1. J Immunol. 1966 Mar;96(3):464-71 - PubMed
    1. Ann Intern Med. 1966 Jul;65(1):9-19 - PubMed
    1. J Lab Clin Med. 1967 Nov;70(5):800-12 - PubMed
    1. Arthritis Rheum. 1968 Oct;11(5):607-17 - PubMed
    1. J Mol Biol. 1972 Jul 14;68(1):107-14 - PubMed

Publication types