doi: 10.1093/infdis/136.1.17.
Pilot studies on recombinant cold-adapted live type A and B influenza virus vaccines
- PMID: 69670
- DOI: 10.1093/infdis/136.1.17
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Pilot studies on recombinant cold-adapted live type A and B influenza virus vaccines
J Infect Dis.
1977 Jul.
Abstract
Recombinant live attenuated type A and B influenza virus vaccines derived from standardized cold-adapted parent strains were given singly and in combination to volunteers. The vaccine viruses were well tolerated, functioned as good antigens, and failed to spread to intimate household contacts. Thirty-nine isolates that were recovered after a single passage in humans appeared genetically stable. The results of histopathologic studies in ferrets encourage development of an animal model for attenuation of the virus.
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