Folate metabolism in filariae. Enzymes associated with 5,10-methenyltetrahydrofolate and 10-formyltetrahydrofolate
- PMID: 6967110
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Folate metabolism in filariae. Enzymes associated with 5,10-methenyltetrahydrofolate and 10-formyltetrahydrofolate
J Parasitol.
1980 Jun.
Abstract
Adult Dirofilaria immitis and Brugia pahangi were found to possess the following folate-related enzymes that catalyze the formation of 5,10-methenyltetrahydrofolate (methenylFH4) or 10-formylFH4 (f10FH4): f10FH4 synthetase, methenylFH4 cyclohydrolase, f5FH4 cyclodehydrase, and a bifunctional complex composed of formiminoglutamate: FH4 formiminotransferase and 5-fomiminoFH4 cyclodeaminase. The properties of these filarial enzymes were generally similar to those of their counterparts from invertebrate and vertebrate sources, although each possessed one or more distinctive characteristics.
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