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. 1980;35(1):35-45.

Pharmacokinetics and metabolism of diltiazem in man

V Rovei, R Gomeni, M Mitchard, J Larribaud, C Blatrix, J J Thebault, P L Morselli
  • PMID: 6967667

Pharmacokinetics and metabolism of diltiazem in man

V Rovei et al. Acta Cardiol. 1980.

Abstract

Dilitazem, a coronary vasodilating agent, after oral administration of four different doses, was well and rapidly absorbed. The pharmacokinetics of the drug followed a two-compartment model, with a rapid distribution and an elimination with a half-life of 4-7 hours. After chronic treatment the pharmacokinetic parameters were practically unchanged and therefore no accumulation of the drug was observed. The comparison between capsule and tablet preparations showed that both forms had a similar bioavailability. Diltiazem was extensively metabilized and only a few percent of the drug was found in urine. Several metabolites, also present as conjugates, have been identified by means of gas chromatography-mass spectrometry.

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