Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1980 Jul;33(7):648-52.
doi: 10.1136/jcp.33.7.648.

Antibody to synthetic poly dAT: correlation with antibody to native DNA and specificity for SLE

P Davis, D Makinen

Antibody to synthetic poly dAT: correlation with antibody to native DNA and specificity for SLE

P Davis et al. J Clin Pathol. 1980 Jul.

Abstract

Antibodies to synthetic 3H-poly dAT have the advantage over antibody to native DNA in that they have a higher degree of specificity for systemic lupus erythematosus (SLE). This is because poly dAT eliminates the problem of measurement of single stranded antibodies that are not specific for any one condition but which may be detected by native DNA preparations which usually contain single stranded regions. The overall degree of correlation between the two antibodies is good in SLE. Antibodies to poly dAT correlate well with clinical evidence of disease activity but in this study were not particularly associated with the presence of renal disease.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. J Mol Biol. 1966 Dec 28;22(2):199-209 - PubMed
    1. N Engl J Med. 1969 Sep 25;281(13):701-5 - PubMed
    1. Ann Rheum Dis. 1971 May;30(3):259-64 - PubMed
    1. J Exp Med. 1971 Jul 1;134(1):294-312 - PubMed
    1. N Engl J Med. 1971 Dec 30;285(27):1502-6 - PubMed

MeSH terms