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. 1980 Dec;125(6):2555-8.

Thymoma production of T cell growth factor (Interleukin 2)

J J Farrar, J Fuller-Farrar, P L Simon, M L Hilfiker, B M Stadler, W L Farrar
  • PMID: 6968789

Thymoma production of T cell growth factor (Interleukin 2)

J J Farrar et al. J Immunol. 1980 Dec.

Abstract

Phorbol-12-myristate-13-acetate stimulates a subline of mouse EL-4 thymoma cells to produce, in vitro, in very high titer, T cell growth factor (Interleukin 2, IL 2). The EL-4-derived IL 2 has the same m.w. (30,000) and isoelectric point heterogeneity (pI 3.8-4.4) as the IL 2 produced by Con A-stimulated spleen cells. In addition, the thymoma-derived IL 2 exhibits the same spectrum of biologic activities as has been reported for spleen cell-derived IL 2.

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