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. 1980 Jul;77(7):4156-9.
doi: 10.1073/pnas.77.7.4156.

Coated pits act as molecular filters

M S Bretscher, J N Thomson, B M Pearse

Coated pits act as molecular filters

M S Bretscher et al. Proc Natl Acad Sci U S A. 1980 Jul.

Abstract

Two proteins--theta and H63 antigens--are found to be excluded from coated pits on fibroblast plasma membranes. Coated pits thus act as molecular filters, pinching off, into the cell, lipid vesicles containing a limited number of specific receptors but excluding other plasma membrane proteins. This constitutes part of a lipid flow cycle that was proposed earlier to explain the capping of crosslinked surface antigens.

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