doi: 10.1073/pnas.77.9.5419.
Selective killing of normal or neoplastic B cells by antibodies coupled to the A chain of ricin
- PMID: 6968912
- PMCID: PMC350070
- DOI: 10.1073/pnas.77.9.5419
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Selective killing of normal or neoplastic B cells by antibodies coupled to the A chain of ricin
Proc Natl Acad Sci U S A.
1980 Sep.
Abstract
Highly specific antibodies (affinity-purified or hybridoma) directed against cell surface immunoglobulins on normal or neoplastic murine B lymphocytes were covalently coupled to the A chain of the plant toxin ricin. Such conjugates containing antibodies specific for IgM, for either of the two allotypes of IgD, or for the idiotype of the B cell tumor BCL1 rapidly bound in vitro to cells expressing the corresponding surface antigen and inhibited protein synthesis in such cells. The results demonstrate that A chain-coupled anti-idiotype antibody may be useful as a tumor-specific cytotoxic agent.
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