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. 1980 Jul;41(1):136-40.

Stimulation of T lymphocytes by protein A from Staphylococcus aureus in B-derived chronic lymphocytic leukaemia

P Guglielmi, J L Preud'Homme

Stimulation of T lymphocytes by protein A from Staphylococcus aureus in B-derived chronic lymphocytic leukaemia

P Guglielmi et al. Clin Exp Immunol. 1980 Jul.

Abstract

Peripheral blood lymphocytes from five untreated patients affected with B-derived chronic lymphocytic leukaemia were stimulated by protein A from Staphylococcus aureus. A very strong response (with stimulation indexes as high as 182 and percentages of blast cells as high as 90%) was found in all patients. Lymphocyte marker studies showed that the responding cells were T cells. These results and the well known abnormalities of lymphocyte response to other mitogens suggest a disbalance of T lymphocyte subpopulations in B-CLL.

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