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. 1981 Apr;78(4):2320-4.
doi: 10.1073/pnas.78.4.2320.

Host restriction of Friend leukemia virus: gag proteins of host range variants

S Duttagupta, R Soeiro

Host restriction of Friend leukemia virus: gag proteins of host range variants

S Duttagupta et al. Proc Natl Acad Sci U S A. 1981 Apr.

Abstract

The host response to murine ecotropic leukemia viruses is mainly controlled by the mouse Fv-1 gene. This locus controls virus replication at an intracellular stage and prevents provirus integration. Biological studies suggest that the Fv-1 effector molecule recognizes at least one virion structural protein. We have produced host range variants of B-tropic Friend murine leukemia virus in order to study the primary structure of potential viral target proteins. Our results show that conversion of B-tropism to NB-tropism is associated with changes in the primary structure of three gag proteins--p15, p12, and p30. These results suggest that host range conversion is due to a recombinational event, presumably between the parental virus and an endogenous murine virus. They also open the possibility that p12 and p30 may be involved in host range restriction.

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