Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1981 Jun;40(3):299-302.
doi: 10.1136/ard.40.3.299.

HLA DR4 and rheumatoid arthritis in Japanese people

H Maeda, T Juji, H Mitsui, H Sonozaki, K Okitsu

HLA DR4 and rheumatoid arthritis in Japanese people

H Maeda et al. Ann Rheum Dis. 1981 Jun.

Abstract

Eighty-eight Japanese patients with rheumatoid arthritis and 104 normal Japanese persons were typed for HLA A, B, C, and DR antigens. The frequency of HLA DR4 was 70.5% in patients compared with 46.1% in normal controls (P less than 0.001). However, a sex difference in the frequency of HLA DR4 in patients was noted. HLA DR4 was found in 80.6% of male patients, which was highly significant compared with controls (P less than 0.0005), while only a borderline increase of 60.5% was found in female patients (P less than 0.05). In addition, the frequency of HLA DR2 was remarkably low in male patients. These suggest the possible heterogeneity of rheumatoid arthritis in Japanese.

PubMed Disclaimer

References

    1. Tissue Antigens. 1980 Feb;15(2):173-6 - PubMed
    1. Arthritis Rheum. 1972 Sep-Oct;15(5):524-9 - PubMed
    1. Lancet. 1972 Dec 30;2(7792):1425 - PubMed
    1. N Engl J Med. 1973 Apr 5;288(14):704-6 - PubMed
    1. N Engl J Med. 1974 Mar 7;290(10):554-6 - PubMed