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. 1978 Aug;14(2):159-64.
doi: 10.1128/AAC.14.2.159.

Carbon catabolite regulation of cephalosporin production in Streptomyces clavuligerus

Carbon catabolite regulation of cephalosporin production in Streptomyces clavuligerus

Y Aharonowitz et al. Antimicrob Agents Chemother. 1978 Aug.

Abstract

Cephalosporin production by Streptomyces clavuligerus is regulated by some type of carbon catabolite control. Increasing concentrations of preferred carbon sources, such as glycerol and maltose, decreased production of the antibiotics. Poorer carbon sources, such as alpha-ketoglutarate and succinate, led to high specific production of cephalosporins and shifted the dynamics of fermentation to a greater degree of association with growth. The results support the concept that the phase in which a product is made by a microorganism is not a function of the particular molecule produced, but rather of the nutritional environment presented to the organism.

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References

    1. Arch Microbiol. 1977 Nov 18;115(2):169-73 - PubMed
    1. Annu Rev Microbiol. 1977;31:343-56 - PubMed
    1. J Antibiot (Tokyo). 1976 Jun;29(6):668-9 - PubMed
    1. J Bacteriol. 1972 Feb;109(2):659-67 - PubMed
    1. Can J Microbiol. 1970 Mar;16(3):173-9 - PubMed

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