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Comparative Study
. 1981;27(3):209-16.

T-Cell hydrids: I. Selection of thymidine kinase deficient subline EL-4R from EL-4 cell population

J Bubeník, J Símová, J Kára, H Kypĕnová, D Bubeníková
  • PMID: 6973493
Comparative Study

T-Cell hydrids: I. Selection of thymidine kinase deficient subline EL-4R from EL-4 cell population

J Bubeník et al. Folia Biol (Praha). 1981.

Abstract

Thymidine kinase deficient (TK-) cell line EL-4R suitable for production of T-cell hybrids has been selected from the EL-4 cell population by treatment with 5-bromodeoxyuridine. Comparison of the EL-4 and EL-4R cell lines revealed differences in chromosome constitution and electrophoretic mobility of both cell populations. Both, EL-4 and EL-4R cells had a modal number of 39 chromosomes; the percentage of cells with modal number of chromosomes and the percentage of biarmed chromosomes in the EL-4R line was higher than that of the EL-4 line. Anodic electrophoretic mobility of EL-4R cell population was faster than that of EL-4 cells, respective mean values being 0.96 and 0.91 X 10(-4) cm2 s-1 V-1.

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