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. 1978 Aug;14(2):270-3.
doi: 10.1128/AAC.14.2.270.

Erythropoietin concentration in amphotericin B-induced anemia

R R MacGregor, J E Bennett, A J Erslev

Erythropoietin concentration in amphotericin B-induced anemia

R R MacGregor et al. Antimicrob Agents Chemother. 1978 Aug.

Abstract

Amphotericin B was given to six patients with systemic fungal infections. A dose averaging 1.78 g, administered from 42 to 144 days, was associated with a fall in hematocrit to a mean value of 25.8%. Despite this degree of anemia, no elevation of erythropoietin concentrations in urine or serum could be detected. Thus, amphotericin appears to cause anemia by inhibiting erythropoietin production rather than by suppressing bone marrow activity directly.

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