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. 1981;101(1):91-100.
doi: 10.1007/BF00405069.

Marker profiles of human leukemia and lymphoma cell lines

J Minowada, H Koshiba, K Sagawa, I Kubonishi, M S Lok, E Tatsumi, T Han, B I Srivastava, T Ohnuma

Marker profiles of human leukemia and lymphoma cell lines

J Minowada et al. J Cancer Res Clin Oncol. 1981.

Abstract

By means of the multiple marker analysis, a total of 55 human leukemia-lymphoma cell lines which included 15 T-cell, 30 B-cell, four myelomonocytic-cell, and six non-T, non-B cell lines was characterized for their marker profiles. The multiple markers used included a number of cell surface markers as detected by either rosette or immunofluorescence tests, enzyme assays, cytogenetic analysis, and certain functional assay. Based on the criteria previously defined it was found that all the cell lines were proved to represent original leukemia-lymphoma of ALL, AML, CLL, CML in blastic phase or variety of lymphomas. The monoclonality, a "frozen" state at a specific state of differentiation-maturation, and cytogenetic marker in each leukemia-lymphoma cell line were remarkable common properties and were stable for years of cultivation. Similar, if not identical, general characteristics were observed in the study on 344 cases of uncultured fresh leukemia-lymphomas by the multiple marker analysis. While no single marker specific to any type of tumor was found, the study offers not only a basis for better understanding of the biology of leukemia-lymphoma but also an insight into normal hematopoietic cell differentiation in man.

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References

    1. Andersson LC, Jokinen M, Gahmberg CG (1979) Induction of erythroid differentiation in the human leukaemia cell line K 562. Nature 278:364–365 - PubMed
    1. Billing R, Rafizadeh B, Drew I, Hartman G, Gale R, Terasaki P (1976) Human B-lymphocyte antigens expressed by lymphocytic and myelocytic leukemia cells. I. Detection by rabbit antisera. J Exp Med 144:167–178 - PMC - PubMed
    1. Bollum FJ (1979) Terminal deoxynucleotidyl transferase as a hematopoietic cell marker. Blood 54:1203–1215 - PubMed
    1. Collins SJ, Ruscetti FW, Gallagher RE, Gallo RC (1978) Terminal differentiation of human promyelocytic leukemia cells induced by dimethyl sulfoxide and other polar compounds. Proc Natl Acad Sci 75:2458–2462 - PMC - PubMed
    1. Epstein AL, Kaplan HS (1974) Biology of the human malignant lymphomas. I. Establishment in continuous cell culture and heterotransplantation of diffuse histiocytic lymphomas. Cancer 34:1851–1872 - PubMed

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