[Effect of rifampicin on body immunological reactivity]

Abstract

The studies with 60 guinea pigs and 111 albino mice showed that the daily use of rifampicin for a prolonged period of time in an oral dose of 30 mg/kg for the guinea pigs and 20 mg/kg for the mice had a pronounced effect on the immunological reactivity of the host. The use of rifampicin for 3 months resulted in changed in the structure of the lymphoid organs and suppression of T-lymphocytes. It had an inhibitory effect on the development of the anaphylactic shock in response to the resolution dose of the foreign serum. The preliminary treatment of the mice with rifampicin for 2 months lowered the primary and to a greater extent the secondary immune response induced by the sheep red blood cells.