Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1981 Nov;44(5):700-8.
doi: 10.1038/bjc.1981.256.

Folate catabolism in tumour-bearing rats and rats treated with methotrexate

A M Saleh, A E Pheasant, J A Blair
Free PMC article

Folate catabolism in tumour-bearing rats and rats treated with methotrexate

A M Saleh et al. Br J Cancer. 1981 Nov.
Free PMC article

Abstract

The metabolism of (2-14C) + (3',5',7,9-3H) folic acid was studied in normal rats, tumour-bearing rats and rats treated with methotrexate (MTX). The experiments were designed to investigate changes in the catabolism and folate. The breakdown of folate to scission products was again demonstrated to be a normal phenomenon. Catabolites excreted included p-acetamidobenzoate, p-acetamidobenzoyl-L-glutamate, 3H2O, urea and a number of pterins. The catabolic process was decreased in the presence of a tumour and increased by the administration of MTX. MTX also led to the excretion of 4 additional radioactive pterins not found in normal urine. The possible mechanisms of folate breakdown are discussed with reference to the point of action of MTX.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Can J Biochem. 1970 Sep;48(9):999-1009 - PubMed
    1. Anal Biochem. 1970 Jul;36(1):197-206 - PubMed
    1. Cancer Res. 1971 Dec;31(12):2177-83 - PubMed
    1. Ann N Y Acad Sci. 1971 Nov 30;186:400-22 - PubMed
    1. Biochem Biophys Res Commun. 1972 Apr 14;47(1):35-43 - PubMed

Publication types