doi: 10.1084/jem.155.1.179.
Suppression of interstitial nephritis by auto-anti-idiotypic immunity
- PMID: 6976412
- PMCID: PMC2186556
- DOI: 10.1084/jem.155.1.179
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Suppression of interstitial nephritis by auto-anti-idiotypic immunity
J Exp Med.
.
Abstract
Rats immunized with renal tubular antigens were protected from the development of interstitial nephritis by pretreatment with tubular antigen-reactive T lymphoblasts. Protected animals developed anti-idiotypic antibodies against idiotypes primarily within the antigen-binding region of monoclonal antitubular basement membrane antibodies. These studies extend the concept of auto-anti-idiotypic regulation to autoimmune disease, and they also provide an experimental basis for further efforts to develop biologically relevant mechanisms for attenuating the expression of other kidney diseases.
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