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. 1981 Dec;13(4):1929-31.

Mechanism of the local antitumor action of inflammation

P Alexander, I B Parr, L E Jackson
  • PMID: 6977224

Mechanism of the local antitumor action of inflammation

P Alexander et al. Transplant Proc. 1981 Dec.

Abstract

Some but not all tumor cells are killed in the environment of a delayed hypersensitivity reaction (DHSR) induced by antigens unrelated to the tumor. Of the several cytotoxic components, cellular and humoral, which are present at the site of a DHSR, a lymphokine released by the interaction of specific antigen with immune T cells-presumptively lymphotoxin-was shown to be responsible for the antitumor action of DHSR. The same mechanism may account for the failure of some tumor cells to grow when inoculated in admixture with BCG.

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