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Comparative Study
. 1978 Aug 1;173(2):475-82.
doi: 10.1042/bj1730475.

Comparative study of the glycosphingolipids of chicken bursa of Fabricius and of chicken, rat and human thymus

Comparative Study

Comparative study of the glycosphingolipids of chicken bursa of Fabricius and of chicken, rat and human thymus

R Narasimhan et al. Biochem J. .

Abstract

1. The glycosphingolipid compositions of the thymus and bursa of Fabricius of young male chickens were compared. The two tissues were found to contain complex mixtures of both neutral glycosphingolipids and gangliosides. Both tissues contained mono-, di-, tri-, tetra- and penta-glycosylceramides; the pentaglycosylceramide displayed a reaction of identity with authentic Forssman antigen when tested against a specific anti-(Forssman antigen) serum. The ganglioside G(m3) containing N-acetylneuraminic acid was the principle ganglioside of both tissues. 2. The thymus contained appreciable amounts of the simple ganglioside N-acetylneuraminylgalactosylceramide, a compound not found in the bursa. The ganglioside G(d3) (disialohaematoside) was detected in both tissues. 3. Rat and human thymus, like sheep thymus (Narasimhan, Hay, Greaves & Murray (1976) Biochim, Biophys. Acta 431, 578-591), both contained a tetraglycosylceramide species as their most complex neutral glycosphingolipid and possessed little or no Forssman antigen. They also contained a complex mixture of gangliosides. 4. The possible significance of these results is briefly discussed.

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References

    1. J Lipid Res. 1964 Apr;5:145-55 - PubMed
    1. Biochem J. 1963 Feb;86:378-82 - PubMed
    1. Biochim Biophys Acta. 1957 Jun;24(3):604-11 - PubMed
    1. J Biol Chem. 1951 Nov;193(1):265-75 - PubMed
    1. Proc Natl Acad Sci U S A. 1977 Jul;74(7):3023-7 - PubMed

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