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. 1982 Mar 1;155(3):943-8.
doi: 10.1084/jem.155.3.943.

Prostaglandin E inhibits the production of human interleukin 2

R S Rappaport, G R Dodge

Prostaglandin E inhibits the production of human interleukin 2

R S Rappaport et al. J Exp Med. .

Abstract

Prostaglandins of the E type specifically inhibited the production of interleukin 2 (IL-2) by normal human lymphocytes, whereas PG synthetase inhibitors such as indomethacin and fentiazac raised IL-2 production above normal levels. Removal of adherent cells from mononuclear cell populations also resulted in enhanced IL-2 production. The resultant nonadherent cell population lost sensitivity to the enhancement effect of PG synthetase inhibitors, suggesting that a PGE-producing adherent cell plays a major role in the regulation of IL-2.

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References

    1. Nat New Biol. 1971 Jun 23;231(25):232-5 - PubMed
    1. Science. 1976 Sep 10;193(4257):1007-8 - PubMed
    1. Nature. 1976 Jul 29;262(5567):401-2 - PubMed
    1. Life Sci. 1977 Mar 15;20(6):903-13 - PubMed
    1. J Exp Med. 1977 Dec 1;146(6):1719-34 - PubMed