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. 1982 Apr;21(4):655-60.
doi: 10.1128/AAC.21.4.655.

Mutational enzymatic resistance of Enterobacter species to beta-lactam antibiotics

M F Lampe, B J Allan, B H Minshew, J C Sherris

Mutational enzymatic resistance of Enterobacter species to beta-lactam antibiotics

M F Lampe et al. Antimicrob Agents Chemother. 1982 Apr.

Abstract

Mutants with enhanced beta-lactam resistance were selected from strains of Enterobacter cloacae and E. aerogenes by using three antibiotics. High-level beta-lactamase-producing mutants had similar degrees of increased resistance, enzyme substrate profiles, and isoelectric (pI) values irrespective of the selective agent. Reverse mutants from a resistant E. cloacae mutant regained the susceptibility pattern originally exhibited by the wild type, or were of enhanced susceptibility, and no longer expressed increased beta-lactamase production. beta-Lactamases of the mutants were similar in pI values to the wild-type enzyme. The increased resistance of the mutants therefore appeared to be accounted for by increased beta-lactamase production.

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References

    1. J Gen Microbiol. 1967 Nov;49(2):277-85 - PubMed
    1. J Bacteriol. 1969 Feb;97(2):961 - PubMed
    1. Antimicrob Agents Chemother (Bethesda). 1968;8:57-63 - PubMed
    1. J Gen Microbiol. 1970 Apr;61(1):43-61 - PubMed
    1. Acta Pathol Microbiol Scand B Microbiol Immunol. 1971;217:Suppl 217:1+ - PubMed

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