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Case Reports
. 1982 Apr;57(4):311-3.
doi: 10.1136/adc.57.4.311.

Liver damage in a neonate with alpha-1-antitrypsin deficiency due to phenotype PiZ null (Z-)

J Burn, D Dunger, B Lake
Case Reports

Liver damage in a neonate with alpha-1-antitrypsin deficiency due to phenotype PiZ null (Z-)

J Burn et al. Arch Dis Child. 1982 Apr.

Abstract

An infant with neonatal liver damage had α-1-antitrypsin deficiency, having inherited the Z allele from the father and the rare null allele from the mother. This indicates that while a lack of serum antiprotease predisposes to early liver disease, homozygosity for the Z allele is not essential.

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