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Comparative Study
. 1982 Jul;46(3):575-81.

T-cell regulation of pokeweed-mitogen-induced polyclonal immunoglobulin production in mice. I. Characterization of helper T cells

T Kina, S Nishikawa, Y Katsura
Comparative Study

T-cell regulation of pokeweed-mitogen-induced polyclonal immunoglobulin production in mice. I. Characterization of helper T cells

T Kina et al. Immunology. 1982 Jul.

Abstract

T-cell regulation of pokeweed mitogen (PWM)-induced polyclonal immunoglobulin (Ig) production was studied in mice. Under optimal stimulating conditions, about 1000 Ig-producing cells were generated per 3 x 10(5) spleen cells and macrophages were required to generate Ig-producing cells from B lymphocytes. The response of splenic B cells to PWM was partially dependent upon helper T cells, whereas the response to lymph node B cells was completely dependent upon T cells. Helper activity was attributed not only to Lyt 1+ 2- but also to Lyt 1+ 2+ T cells. Co-operation between T and B cells, in this system, was not restricted by H-2 barrier.

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