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Clinical Trial
. 1982 Feb;58(676):87-91.
doi: 10.1136/pgmj.58.676.87.

Tranexamic acid therapy in ulcerative colitis

D Hollanders, J M Thomson, P F Schofield
Clinical Trial

Tranexamic acid therapy in ulcerative colitis

D Hollanders et al. Postgrad Med J. 1982 Feb.

Abstract

The antifibrinolytic drug tranexamic acid was assessed in controlling bleeding in 12 patients with left-sided proctocolitis. The study was designed as a double-blind cross-over trial employing a dose of 4·5 g of tranexamic acid/day together with identical placebo. A statistically significant reduction in rectal bleeding was achieved in 50% of cases with a minimum of side effects. Sigmoidoscopic grading of rectal mucosal appearances was improved. Frequency of diarrhoea and stool consistency were not altered.

Tranexamic acid may have a part to play in the management of selected patients with ulcerative colitis in whom bleeding is difficult to control with orthodox treatment.

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