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. 1982 Jun;15(6):1167-8.
doi: 10.1128/jcm.15.6.1167-1168.1982.

Rapid detection in spinal fluid of beta-lactamase produced by ampicillin-resistant Haemophilus influenzae

W H Boughton

Rapid detection in spinal fluid of beta-lactamase produced by ampicillin-resistant Haemophilus influenzae

W H Boughton. J Clin Microbiol. 1982 Jun.

Abstract

The chromogenic cephalosporin nitrocefin was used to detect the presence of beta-lactamase in cerebrospinal fluid of patients suffering from ampicillin-resistant Haemophilus influenzae meningitis. Five samples of spinal fluid containing ampicillin-resistant isolates were studied, and all had beta-lactamase activity. When samples of spinal fluid containing 33 ampicillin-sensitive isolates and 234 sterile specimens were tested, no beta-lactamase activity was detected.

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