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. 1978 Sep 11;512(1):223-6.
doi: 10.1016/0005-2736(78)90233-x.

The susceptibility of cholesterol-depleted erythrocytes to saponin and sapogenin hemolysis

R Segal, I Milo-Goldzweig

The susceptibility of cholesterol-depleted erythrocytes to saponin and sapogenin hemolysis

R Segal et al. Biochim Biophys Acta. .

Abstract

The assumption that complex formation between erythrocyte membrane cholesterol and saponins or sapogenins is the cause for their hemolytic activity, was tested by measuring the susceptibility of cholesterol-depleted erythrocytes towards these hemolysins. For some of the hemolysins cholesterol depletion caused inhibition of hemolysis, for others an augmentation. The results suggest that cholesterol does not serve as a specific binding site for these hemolysins.

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