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. 1982 Nov 1;156(5):1539-44.
doi: 10.1084/jem.156.5.1539.

A monoclonal anti-DC1 antibody selectivity inhibits the generation of effector T cells mediating specific cytolytic activity

G Corte, A Moretta, M E Cosulich, D Ramarli, A Bargellesi

A monoclonal anti-DC1 antibody selectivity inhibits the generation of effector T cells mediating specific cytolytic activity

G Corte et al. J Exp Med. .

Abstract

The products of the DC locus have been shown to be structurally different from those of the DR locus. In this paper it is shown that, unlike anti-DR antibodies, a monoclonal antibody directed against DC1 does not affect proliferation of T cells in response to alloantigens or soluble antigens or production of Ig in a pokeweed mitogen-stimulated in vitro culture. However, the anti-DC1 inhibits the generation of effector T cells mediating specific cytolytic activity, whereas no inhibitory effect can be observed on natural killer and antibody-dependent cytotoxic cell activities.

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