[Transsynovial kinetics and correlation of dosage and effect of non-steroidal anti-rheumatic agents]

Abstract

For NSAID's the clinical evidence of their efficacy is evaluated empirically employing tedious procedures. For diclofenac, indometacin and piroxicam proposals for a more rational procedure of their dose-response relationship determination are discussed. Preclinical data regarding the prostaglandin inhibition are correlated with pharmacokinetic parameters of target-tissue concentrations. In the range of inhibitory drug concentrations in the synovial fluid an antiinflammatory and analgesic effect can be established clinically. Studies on transsynovial kinetics of NSAID's therefore should supply appropriate evidence for an approach to their therapeutic regimen in clinical dose finding studies.