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. 1978 May-Jun;28(3):141-3.

Drug tolerance and biomembranes

J H Chin, D B Goldstein
  • PMID: 698336

Drug tolerance and biomembranes

J H Chin et al. Biomedicine. 1978 May-Jun.

Abstract

Our understanding of the structure and function of biomembranes is now at a stage where we can begin to examine drug actions on the membrane bilayer. Cells need a certain optimal degree of fluidity in their membranes and some organisms can adapt their membrane composition to maintain the appropriate fluidity under changing environmental conditions. Chronic administration of membrane-disrupting drugs may evoke such an adaptive process, which would show itself in vivo as drug tolerance.

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