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. 1982 Nov;79(22):7004-8.
doi: 10.1073/pnas.79.22.7004.

Leukemia-derived growth factor (non-interleukin 2) produced by a human malignant T lymphoid cell line

C H Uittenbogaart, J L Fahey

Leukemia-derived growth factor (non-interleukin 2) produced by a human malignant T lymphoid cell line

C H Uittenbogaart et al. Proc Natl Acad Sci U S A. 1982 Nov.

Abstract

A growth factor was found in the supernatants of MOLT-4f, a cell line derived from acute T lymphoblastic leukemia. This factor, which we designated leukemia-derived growth factor from MOLT-4f (LDGF-M4), is different from interleukin 2. LDGF-M4 has features of a polypeptide with a molecular weight in the range of 5,000-15,000, as indicated by gel diffusion chromatography. LDGF-M4 does stimulate MOLT-4f and at least two other T cell lines that do not respond to interleukin 2. Because MOLT-4f cells produce and respond to LDGF-M4, this factor may contribute to the independence of MOLT-4f and related T leukemia cell lines.

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References

    1. J Natl Cancer Inst. 1966 Aug;37(2):167-75 - PubMed
    1. J Exp Med. 1972 Feb 1;135(2):255-66 - PubMed
    1. Science. 1976 Sep 10;193(4257):1007-8 - PubMed
    1. Annu Rev Biochem. 1976;45:531-58 - PubMed
    1. J Immunol. 1977 Jul;119(1):131-8 - PubMed

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