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. 1982;62(2):139-41.
doi: 10.1007/BF00282302.

PI (alpha 1-Antitrypsin) subtypes: frequency of PI*M4 in several populations

E C Klasen, A Bos, H D Simmelink

PI (alpha 1-Antitrypsin) subtypes: frequency of PI*M4 in several populations

E C Klasen et al. Hum Genet. 1982.

Abstract

Sera from different populations (Dutch, Northern and Southern Italians and Spaniards) were screened for PI (alpha 1-antitrypsin) types and subtypes. A polyacrylamide isoelectric focusing method was applied, which consisted of the combined use of an ultra-thin highly cross-linked gel, restricted pH range carrier ampholytes and a separator. This technique enabled easy typing and subtyping of all known PI phenotypes including PI*M subtypes. The frequency of the new PI*M4 allele was lowest of all PI*M alleles (0.0476 in The Netherlands, 0.0371 in Northern Italy, 0.0308 in Southern Italy and 0.0146 in Spain).

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