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Comparative Study
. 1982;29(4):717-25.

[Changes in lymphoblastic transformation in preleukemic AKR/J mice]

[Article in Spanish]
M C Alonso, A Torres, R Solana, M R Manzanares, J Peña
  • PMID: 6985428
Comparative Study

[Changes in lymphoblastic transformation in preleukemic AKR/J mice]

[Article in Spanish]
M C Alonso et al. Rev Esp Oncol. 1982.

Abstract

The authors investigate the efficacy of the immune system along the AKR/J mouse life span. They employ the phytohemagglutinin (PHA)-induced lymphoblastic transformation test. The response is compared with the immune response obtained in BALB/C mice of the corresponding age. The blastic transformation was significatively lower at 15, 25 and 35 weeks in the AKR/J mouse than in the BALB/C mouse. At the age of 45 weeks the AKR/J mouse shows an increased proportion of lymphocytes in the thymus and spleen, a weight increase of these organs, and an augmented lymphoblastic transformation in response to PHA. This phenomena are not observed in the BALB/C mouse. When macrophages are removed from the lymphocytes preparation, the PHA-induced blastic transformation of lymphocytes is not produced at any age in either AKR/J or BALB/C mice strains.

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