Alteration of myoelectric activity of small intestine by invasive Escherichia coli

Abstract

Invasive strains of Escherichia coli (4608-58 and TD 213 CL) altered myoelectric activity of the small intestine in New Zealand White rabbits. The altered myoelectric activity had two distinct complex patterns. The first was defined as repetitive bursts of action potentials (RBAPs) that occurred predominantly in infected ligated ileal loops. The RBAP activity is characterized by action potential discharge activity greater than 1.5 s in duration and occurring on three or more successive slow waves on the same electrode recording site. These bursts of action potentials often migrated to adjacent electrode sites. The second complex pattern, defined as the migrating action potential complex (MAPC), occurred predominantly in the uninfected small intestine orad to the ligated ileal loop. The MAPC consists of action potential discharge activity of 2.5 s or longer that propagates aborally over at least two consecutive electrode sites. These studies demonstrated an altered myoelectric pattern, the RBAP, characteristic of invasion within the infected ligated loop. The MAPC, characteristic of noninvasion, was noted in the uninfected proximal small intestine.