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. 1980 Jan;18(1):69-71.
doi: 10.1007/BF01228306.

Effect of age on glucose oxidation by isolated rat islets

G M Reaven, P D Reaven

Effect of age on glucose oxidation by isolated rat islets

G M Reaven et al. Diabetologia. 1980 Jan.

Abstract

Islets were isolated from pancreases of 2-month and 12-month-old rats, and the oxidation of 14C-glucose to 14CO2 determined at various medium D-glucose concentration. Islets from 12-month-old rats oxidized significantly less glucose than those from 2-month-old rats at glucose concentrations of 150, 300, and 450 mg/dl, and this was true when islets were selected by hand or by Ficoll density gradient separation. The effect of age on glucose oxidation was seen when islets were incubated with [U-14C], [1-14C], or [6-14C] glucose. The results raise the possibility that previously reported age-related defects in glucose-stimulated insulin secretion may be secondary to the effect of age on islet glucose catabolism.

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