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. 1978 Sep;25(5):366-72.
doi: 10.1007/BF03006565.

Hypoxic ventilatory responses during thiopentone sedation and anaesthesia in man

R L Knill, S Bright, P Manninen

Hypoxic ventilatory responses during thiopentone sedation and anaesthesia in man

R L Knill et al. Can Anaesth Soc J. 1978 Sep.

Abstract

We have assessed the impact of thiopentone on the hypoxic ventilatory reflex, and on the responses to carbon dioxide and doxapram. Thiopentone sedation did not detectably alter any of these aspects of ventilatory control. Thiopentone anaesthesia reduced ventilation and the ventilatory responses to hypoxia, carbon dioxide and doxapram, all approximately in paralle. We conclude that, in contrast to halothane, thiopentone does not selectively reduce the ventilatory response to hypoxia. During light thiopentone anaesthesia, a reasonably brisk hypoxic response is present.

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