doi: 10.1111/j.1365-2184.1980.tb00466.x.
Variability of short-term cultures of HeLa S-3 cells: changes in DNA distributions and rates of DNA synthesis
- PMID: 6989506
- DOI: 10.1111/j.1365-2184.1980.tb00466.x
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Variability of short-term cultures of HeLa S-3 cells: changes in DNA distributions and rates of DNA synthesis
Cell Tissue Kinet.
1980 May.
Abstract
DNA distributions of HeLa S-3 cells in spinner culture exhibit significant time-dependent changes. The major differences appear to occur in the S-phase region. Significant changes in the rates of DNA synthesis in several S-phase subcompartments correlated well with the changes in the DNA distributions. It is proposed that fluctuations in these rates of DNA synthesis are a reflection of the inherent instability of these abnormal, heteroploid cells.
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