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. 1980 Jun 1;151(6):1563-8.
doi: 10.1084/jem.151.6.1563.

Murine pancreatic beta-cells express H-2K and H-2D but not Ia antigens

D Faustman, V Hauptfeld, J M Davie, P E Lacy, D C Shreffler

Murine pancreatic beta-cells express H-2K and H-2D but not Ia antigens

D Faustman et al. J Exp Med. .

Abstract

Direct microcytotoxicity testing and absorption analyses were employed to determine whether H-2K, H-2D, and Ia antigens are present on murine islet of Langerhans cells. Products of the H-2K and H-2D loci were found on beta-cells from three different mouse strains, but I-region (Ia) antigens were not detected. The absence of Ia gene products from islet cells may be of importance in explaining the survival of islet allografts across major histocompatibility barriers.

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