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. 1980 Apr;178(1):233-5.
doi: 10.1007/BF00267235.

Curing of Escherichia coli K12 plasmids by coumermycin

O N Danilevskaya, A I Gragerov

Curing of Escherichia coli K12 plasmids by coumermycin

O N Danilevskaya et al. Mol Gen Genet. 1980 Apr.

Abstract

Low concentrations of the antibiotic coumermycin A1, the inhibitor of bacterial DNA gyrase, effectively eliminate pBR322, pMB9 and other ColE 1 related plasmids from E. coli K12 strains. The curing action of antibiotic seems to result from the plasmid degradation and not just from the inhibition of replication.

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References

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